Glossary On Causes

Can anyone explain what caused me to land up with this?

An interesting thing about ankylosing spondylitis is that the exact cause of this condition has not been clearly understood till date though it has been the subject of numerous studies!

Ankylosing spondylitis is considered to be a genetic disorder in which the HLA-B27 gene in particular has an important role to play. People with this particular gene have a significantly higher risk of developing ankylosing spondylitis. However, it must be noted that not every person who has the HLA-B27 gene develops this disorder. Thus there are some additional factors, probably environmental, that are involved in the development of this condition.

Patients with a family history of ankylosing spondylitis stand a greater chance to develop it as compared to those with no family history.

In addition, gender predilection has been strongly noticed in this condition. Males are almost 2 to 3 times more prone to develop this condition as compared to females.

The initial inflammation that activates the immune system is thought to be triggered by a bacterial or microbial infection. At a later stage, the immune system is unable to turn off this response which continues to attack the body’s own tissues now, in this case, the joints leading to arthritis. This explains the auto-immune nature of the disease.

Ankylosing Spondylitis